Clinical Trials & Research

The protein adipsin, which is produced in body fat, helps protect insulin-secreting cells called pancreatic beta cells from destruction in type 2 diabetes, according to a new study by researchers at Weill Cornell Medicine and NewYork-Presbyterian. Among middle-aged adults, higher levels of the protein in the blood were also associated with protection from type 2

Nov 8 2019 Sartorius is excited to announce publication of the third edition of our Live-Cell Analysis Handbook, a popular publication for a broad range of scientists who perform cell biology assays as part of their research. Since its launch, we have filled more than 3,500 requests for downloads and hard copies. In this latest

Polyamides are plastic polymers, built up from monomers or identical building blocks assembled in a repeating pattern. During this process, some shorter chains, or oligomers, are produced inadvertently. These remain in the plastic material. The problem arises when the plastic is used to make a food dish, because if the food is hot, the oligomers

Opioid addiction is among the biggest medical conditions troubling the U.S. today, and is far from reaching a solution. In 2017, it claimed almost 50 deaths per 100,000 in the state of West Virginia – the highest drug-overdose-related death rate in the US. Today, however, there is a gleam of hope from a new trial

Eisai Co., Ltd. announced today that it has entered into an agreement to transfer the rights to receive royalties on the sales outside of Japan for an investigational anti-cancer agent tazemetostat (generic name) to Royalty Pharma. Tazemetostat is a first-in-class, oral EZH2 inhibitor discovered by Epizyme, Inc. Under the terms of the March 2015 amended

The UK will be transformed into a global hub for radiotherapy research, pioneering the use of the latest techniques such as FLASH radiotherapy and artificial intelligence, with a new £56 million research network announced by Cancer Research UK today (Monday). The network, Cancer Research UK RadNet, is the charity’s largest ever investment in radiotherapy research

A research team at The University of Tokyo has reproducibly synthesized staircase-like supramolecules of a single handedness, or chirality, using standard laboratory equipment. By gradually removing the solvent from a rotating solution containing non-chiral precursors, they were able to produce helixes that twist preferentially in a particular direction. This research may lead to new and

Rare diseases are by their very nature obscure and unknown, falling through the cracks when it comes to research budgets and treatment development. But now, a study has shown they are more common than we think. New research shows that rare diseases are not that rare. The United States classifies a rare disease as one

A national survey of acute and critical care nurses finds that measures to reduce unnecessary testing and treatments are increasingly being integrated into clinical practice, even though most respondents are not aware of the campaign behind the specific recommendations. A multidisciplinary Critical Care Societies Collaborative (CCSC) work group conducted the survey to assess awareness and

There are many and various receptors on the surface of each human cell, which bind to specific molecules called ligands, to set off signals that modulate cell activity accordingly. These pathways are exploited by therapeutic drugs. In fact, one in three drugs makes use of receptors belonging to a single very large family – the

Lean thinking -; the philosophy of maximizing customer value while minimizing waste -; has long been hailed as a panacea for low productivity and poor performance. Introduced decades ago through the famed Toyota Production System, today lean is moving beyond its factory-floor applications. It is slowly making inroads in the U.S. health care system, which

A custody case in Texas has sparked heated debate and embroiled state policymakers in public discussions about the diagnosis and appropriate medical treatment of transgender children. Unfortunately, many of the claims being made about gender-affirming care for transgender and gender incongruent individuals are inaccurate. Policies concerning the diagnosis and treatment of transgender individuals should be

Currently available flu vaccines are based on the rapidly changing viral hemagglutinin (HA) antigen, and are therefore quickly outdated. Thus new vaccines need to be developed each year. Now, a new study published in the journal Science on October 25, 2019, reports on a set of three novel antibodies that bind to another type of

On October 24, 2019, cystic fibrosis (CF) patients rejoiced at the news that three years of talks between the UK’s National Institute for Health and Care Excellence (NICE) and Vertex Pharmaceuticals had succeeded in a compromise which could see about 5,000 patients gaining access to a potentially life-saving drug called Orkambi within the next month.

A new study published in the journal Neuron on October 9, 2019 reports that scientists have unlocked part of the secrets of the SETD1A gene – how mutations in the gene put the individual at risk for the condition. The researchers inactivated this gene, which they call “a master regulator”, in a mouse model, producing

Atopic dermatitis is a common form of eczema that affects millions of people in the United States. Now, a new proof-of-concept study suggests that a novel drug could relieve symptoms after just one dose. Share on PinterestA new treatment for atopic dermatitis shows promise in proof-of-concept trial. Researchers estimate that about 16.5 million adults in

Mohanraj Thirumalai, Ph.D., has received a three-year National Institute on Disability, Independent Living and Rehabilitation Research grant to investigate and develop an artificial intelligence-assisted telecoaching solution for people with disabilities and diabetes. Think of the virtual assistant apps, plus the apps that give you recommendations, and then think about how they can work for health

NYU Langone Health and its Perlmutter Cancer Center have launched clinical whole genome DNA methylation profiling for patients with brain tumors. This leading-edge molecular assay utilizes DNA epigenetic signatures and artificial intelligence with machine learning to correctly identify and subtype brain tumors. NYU Langone Health is the first Clinical Laboratory Improvement Amendments (CLIA)-certified laboratory in

Chronopharmacology or chronotherapy deals with the effects of a drug when taken at specific time of the day. This variable response to medication is due to the 24 hour biological clock or circadian rhythm of the body say experts. Image Credit: Tero Vesalainen A new study has revealed that taking high blood pressure or hypertension

A startling presentation at UEG Week 2019, in Barcelona, reveals that the gut microbiome is at high risk for damage each time we use a drug from one or more of 18 commonly used groups. The effects may range from changes in the relative proportions of different beneficial and potentially harmful species to alterations in

Each year, more than 350,000 cardiac arrests occur outside the hospital, and almost 40% of those occur in public places. Effective cardiopulmonary resuscitation (CPR) provided by a bystander in the first few minutes of cardiac arrest can double or triple a victim’s chance of survival. However, less than 20% of Americans are equipped to perform

Colorectal surgery patients who were a part of an enhanced recovery after surgery (ERAS) program had less pain, while using nearly half as many opioids, according to research being presented at the ANESTHESIOLOGY® 2019 annual meeting. ERAS protocols focus on reducing the use of opioids while minimizing pain, expediting patient recovery, decreasing complications and shortening

We already have vaccines that prevent influenza, but there is a catch. Specialists have to keep creating vaccines that target specific flu strains if they want this preventive strategy to be effective. Can scientists create one flu vaccine to rule them all? Is a universal flu vaccine on the way? Influenza — which people commonly

Alleviating food insecurity is often seen as one of the fundamental roles a country should fulfill. In some cases, this is encapsulated into a constitutionally formalized “right to food”. In other cases, including the U.S., the right to food isn’t formalized, but the U.S. government spends billions of dollars per year to help Americans obtain

A team of Salk scientists led by Professor Martyn Goulding has been awarded $14.3 million over five years by the National Institutes of Health (NIH) to create a high-resolution atlas of how the mouse brain generates and controls skilled forelimb movements, such as reaching and grasping. Knowledge generated by the grant will provide a better

Exercise has always been a measure to maintain a healthy weight. Being overweight and obese has been tied to a multitude of health complications, such as type 2 diabetes and cardiovascular disease. Engaging in physical activities has many health benefits and may help with weight loss. Image Credit: Brocreative / Shutterstock Now, a new study

The Ebola virus disease (EVD) is a deadly infection that is highly contagious. It has taken thousands of lives across history, with a number of outbreaks mostly happening in West Africa. In the worse outbreak, between 2014 and 2016, there had been 28,616 cases of EVD, 11,310 of whom had died in the continent. Overseas,

Finding out how kinesiophobia -unreasonable fear of movement- may affect individuals with chronic musculoskeletal pain is the aim of a research group of the University of Malaga (UMA), which recent studies have been published in the scientific journal British Journal of Sports Medicine, the world’s number 1 publication in the locomotor system field. After several