A team from Roswell Park Comprehensive Cancer Center is moving a new three-part strategy for treating advanced cancers forward with support from a U.S. Department of Defense (DoD) grant to Pawel Kalinski, MD, PhD, Vice Chair for Translational Research and Rustum Family Professor for Molecular Therapeutics and Translational Research at the Buffalo, N.Y.-based cancer center.
Clinical Trials & Research
Two surgical procedures used to repair vaginal prolapse -; one involving removal of the uterus via hysterectomy and the other employing mesh support that preserves the uterus -; have comparable clinical outcomes after three years, according to new data from researchers at University of California San Diego School of Medicine. The results are published in
Methanol is sometimes referred to as ethanol’s deadly twin. While the latter is the intoxicating ingredient in wine, beer and schnapps, the former is a chemical that becomes highly toxic when metabolized by the human body. Even a relatively small amount of methanol can cause blindness or even prove fatal if left untreated. Cases of
The body’s immune response fights against infectious disease, and it safeguards against future infections through vaccination. However, if the immune response dysfunctions and attacks the body itself, it can cause autoimmune disease. Thus, a healthy immune response balances an instant readiness to combat infecting viruses or bacteria, while maintaining benign surveillance of the body’s own
Researchers at the Complutense University of Madrid (UCM) have identified changes in retinal layer thickness, inflammation or thinning in patients with mild Alzheimer’s disease, confirming that the retina is one of the most important biomarkers for early diagnosis of the disease. For the first time, researchers have determined the shape and size of the areas
A new study on menopausal women shows that leisure-time physical activity is associated with a healthier blood lipid profile. However, results suggest that leisure-time physical activity does not seem to entirely offset the unfavorable lipid profile changes associated with the menopausal transition. Women experience a rapid increase in cardiovascular disease (CVD) risk after the onset
There are 157 organisms that form the baseline biome of a healthy human gut, according to research published in the journal PLOS ONE by investigators at the George Washington University (GW). The baseline microbial profile, called GutFeelingKB, can be expanded to 863 organisms if closely related proteomes are considered. This information will serve as a
The proportion of young people in Finland diagnosed with depression in specialized services is increasing, showed a study based on an extensive set of national data. An increasing number of adolescents seek and get help, but the increase in service use burdens specialized services. The study was conducted by the Research Centre for Child Psychiatry
New tools for editing genetic code offer hope for new treatments for inherited diseases, some cancers, and even stubborn viral infections. But the typical method for delivering gene therapies to specific tissues in the body can be complicated and may cause troubling side effects. Researchers at the University of Wisconsin–Madison have addressed many of those
A fundamental question in nerve biology brings to mind a race car at the starting line: The engine is revving, but the brake is on. The system is ready to go, but under tight control. And when the light flashes green, the car blasts away from the line. A similar process occurs at junctions between
The International Association for the Study of Lung Cancer today used the platform of its largest international meeting to call attention to the importance of tobacco cessation after cancer diagnosis, and urged all physicians to screen cancer patients for tobacco use and recommend tobacco cessation. Cancer patients who continue smoking after their diagnosis have a
One of the first studies of its kind focusing on South African children’s language ability and mental health outcomes, has found clear evidence for a link between low language ability and depression in young people. The study, published today in the journal PLOS One from researchers at the University of Bath (UK) and Stellenbosch University
Vitamin D is essential for strong bones. This is universally agreed upon. We also know vitamin D is manufactured in our skin cells when exposed to as little as 10-15 minutes of the summer sun over most of the body surface. However, for people in cold northern climes, this kind of sun is rare for
As voters fume about the high cost of health care, politicians have been targeting two well-deserved villains: pharmaceutical companies, whose prices have risen more than inflation, and insurers, who pay their executives millions in salaries while raising premiums and deductibles. Although the Democratic presidential candidates have devoted copious airtime to debating health care, many of
Most people over age 50 say they’re ready for natural disasters and emergency situations, but a new national poll shows that many haven’t taken key steps to protect their health and well-being in case of severe weather, long-term power outages or other situations. Less than half have signed up for emergency warning systems offered by
More than 70 per cent of cardiovascular disease (CVD) and deaths around the world may be attributed to a small number of common but modifiable risk factors. A large international study, involving more than 155,000 people in 21 countries, has found some of the risks are the same around the world, such as hypertension or
Experts are warning that eyelash treatments are causing a surge in emergency eyelid procedures and serious infections. One of the most commonly reported problems is a condition known as blepharitis; a chronic inflammatory disorder of the eyelids that arises due to bacterial overgrowth on the eyelashes, explains Consultant Ophthalmic and Oculoplastic Surgeon Elizabeth Hawkes in
Low-density lipoprotein (LDL) cholesterol levels should be lowered as much as possible to prevent cardiovascular disease, especially in high and very high risk patients. That’s one of the main messages of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS) Guidelines on dyslipidaemias published online today in European Heart Journal, and on the
A Florida State University researcher is examining how the polyphenol compounds found in blackberries could be used to help fight the buildup of artery plaque. Gloria Salazar, associate professor of nutrition, has received $805,409 from the James and Esther King Biomedical Research Program at the Florida Department of Health to look at the protective effects
From a planning perspective, Wolfgang Balzer is the perfect health care consumer. Balzer, an engineer, knew for several years he had a hernia that would need to be repaired, but it wasn’t an emergency, so he waited until the time was right. The opportunity came in 2018 after his wife, Farren, had given birth to
Aug 29 2019 Postnova Analytics has published a new application note that demonstrates the promise of Electrical Asymmetric Field Flow Fractionation (EAF4) technology for separation and characterization of nanoplastics in the environment. The widespread use of plastics has created one of the worst human-created environmental disasters of current times. Typically formed by the weathering and
Aug 28 2019 There are 1.2 million Australians currently living with a communication disability, which can affect relationships, employment, education and social inclusion. Speech Pathology Australia is already putting a spotlight on this “hidden” disability through the course of Speech Pathology Week (25-31 August), which is well underway. Speech Pathology Australia’s Acting National President, Belinda
There is a growing demand for diagnostic markers for early disease detection and prognosis. Exosomes are potential biomarkers for cancer progression and neurodegenerative disease but it can be difficult to identify what tissue a specific exosome comes from. Researchers at Uppsala University and spin-off company Vesicode AB have solved this problem by developing a method
Daniella Mohazab didn’t know what to expect from her first pelvic exam in 2016. The University of Southern California sophomore, then 19, was startled when her doctor examined her vagina for several minutes without gloves, but assumed it was standard procedure. It wasn’t until two years later, when she read about Dr. George Tyndall’s alleged
Caregivers of people with dementia lose between 2.5 to 3.5 hours of sleep weekly due to difficulty falling asleep and staying asleep — a negative for themselves and potentially for those who receive their care, Baylor University researchers say. But the good news is that simple, low-cost interventions can improve caregivers’ sleep and functioning. The
If you’re a middle-aged or older adult saving for retirement, it’s never too late to think about adding physical activity to your investment portfolio, according to an article in the September issue of ACSM’s Health & Fitness Journal®, an official journal of the American College of Sports Medicine(ACSM). The journal is published in the Lippincott
Public health experts in the US have discovered that the Zika virus may still be spreading in the Americas, despite case reporting having approached close to zero. Shutterstock | nechaevkon Using a framework that integrated local case reporting and travel surveillance with genomic epidemiology, the team discovered a hidden, on-going Zika outbreak in Cuba that
A team at the Keck School of Medicine of USC, in collaboration with The Michael J. Fox Foundation for Parkinson’s Research (MJFF), has just added a crucial new element – RNA sequencing data — to its robust study of Parkinson’s disease. RNA sequencing involves analyzing blood samples to understand how genetic scripts are expressed in